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Massachusetts General Hospital (often abbreviated to "Mass General" or just "MGH") is a teaching hospital of Harvard Medical School and a biomedical research facility in Boston, Massachusetts.

It is owned and operated by Partners HealthCare (which also owns Brigham and Women's Hospital and North Shore Medical Center). MGH is part of the consortium of hospitals which operates Boston MedFlight and is a member of the Dana-Farber/Harvard Cancer Center.

Founded in 1811, the original hospital was designed by the famous American architect Charles Bulfinch. It is the third oldest general hospital in the United States, and the oldest and largest in New England. John Warren, Professor of Anatomy and Surgery at Harvard Medical School, which was located in Cambridge then, spearheaded the move of the medical school to Boston. Warren's son, John Collins Warren, along with James Jackson, led the efforts to start the Massachusetts General Hospital. Since all those who had sufficient money were cared for at home, Massachusetts General Hospital, like most hospitals that were founded in the 19th century, was intended to care for the poor. During mid- to late-1800s, Harvard Medical School was located adjacent to Massachusetts General Hospital.

The hospital's work with developing specialized computer software systems for medical use in the 1960s lead to the development of the MUMPS programming language, which stands for "Massachusetts General Hospital Utility Multi-Programming System", an important programming language and data-base system heavily used in medical applications such as patient records and billing. A major patient database system called File Manager, which was developed by the Veterans Administration (now the Department of Veterans' Affairs), was created using this language.

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